Overview: Covering the epidemiology, pathological changes, molecular pathogenesis and clinical treatments of coal-burning type of endemic fluorosis.Summarizing the latest research developments in the endemic fl.Endemic fluorosis is caused by excessive intake of fluorine in drinking water, air, food, tea and other media in a specific natural environment for a long time, which involves at least 25 countries, such as China, India, Vietnam, Iran, Egypt, Mexico, Argentina and influences more than 200 million of population. China and India are the countries with the most extensive endemic fluorosis
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