Titlebook: Cell Signaling During Mammalian Early Embryo Development; Henry J. Leese,Daniel R. Brison Book 2015 The Editor(s) (if applicable) and The

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Amino Acids and Conceptus Development During the Peri-Implantation Period of Pregnancy,regnancy during the critical peri-implantation period of pregnancy when the stage is set for implantation and placentation that precedes fetal development. Uterine epithelial cells secrete and/or transport a wide range of molecules, including nutrients, collectively referred to as histotroph that ar

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The Role of Hexosamine Biosynthesis and Signaling in Early Development,ul culture in a defined medium, now more than 50 years ago (Whitten, Nature 177:96, 1956), it is only recently that we have begun to appreciate the impact of the environment on life-course trajectory. The mechanisms involved in how nutrient availability may potentially modulate developmental potenti

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Molecular Biology of the Stress Response in the Early Embryo and its Stem Cells,ummation of maternal hormones, and other elements of the maternal milieu, that signal preparedness for development and implantation. Examples discussed here are leptin, adrenaline, cortisol, and progesterone. These hormones signal maternal nutritional status and provide energy, but also signal stres

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Survival Signalling in the Preimplantation Embryo,or exogenous mitogenic or survival signals. This distinguishes the behaviour of cells in the early embryo from all other normal cells. The discovery that fertilisation triggers the production and release of potent bioactive mediators by the embryo that act back on membrane receptors demonstrated the

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Female Tract Cytokines and Developmental Programming in Embryos,that cytokines emanating from the oviduct and uterus confer a sophisticated mechanism for ‘fine-tuning’ of embryo development, influencing a range of cellular events from cell survival and metabolism, through division and differentiation, and potentially exerting long-term impact through epigenetic

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