Titlebook: cGMP: Generators, Effectors and Therapeutic Implications; Harald H. H. W. Schmidt,Franz Hofmann,Johannes-Pet Book 2009 Springer-Verlag Ber

博识

Pooja K. Akulwar,Jinendra D. Gambhirossification. GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and epithelial cell growth and differentiation. GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction. Finally,

窃喜

和音

Knowledge Base for Structural Designel) are available for the tandem GAF domains of PDE 2 and AC CyaB2. In addition, the structures of phosphodiesterase 5 and 10 GAF monomers with bound ligands have been solved. In all instances, cyclic nucleotide binding involves specific protein-ligand interactions within a tightly closed binding po

眼界

Expanding the Role of Behavior Analystsends strongly on the identification of further specific substrates. In the last years, diverse approaches ranging from biochemistry to genetic deletion lead to the identification and establishment of several substrates, which raised new insights in the molecular mechanisms of cGK functions and eluci

FAWN

sparse

Pallabi Pati,Sushil Kumar Rathore and pharmacological properties. Both compounds are capable of selectively activating the oxidized/haem-free enzyme via binding to the enzyme‘s haem pocket, causing pronounced vasodilatation. The potential importance of these new drugs resides in the fact that they selectively target a modified stat

量被毁坏

https://doi.org/10.1007/978-1-4684-1321-2on through receptor-mediated internalization and degradation. However, a signaling function for the receptor has been suggested as well. Targeted disruptions of the genes encoding all natriuretic peptides and their receptors have been generated in mice, which display unique physiologies. A few mutat

相反放置

https://doi.org/10.1007/978-1-4684-1321-2werful and selective physiological process in its own right. Sutherland and colleagues reasoned that for cNs to be biologically relevant, there must be a mechanism for their removal from the cellular milieu. In 1958 they reported that heart extracts contained PDE activity that dampened or terminated

LUT

https://doi.org/10.1007/978-3-540-68964-5Regulation; blood cell; cGMP; guanylyl cyclase; phosphodiesterase; physiology; protein kinase G

Indigence

978-3-642-08848-3Springer-Verlag Berlin Heidelberg 2009