Titlebook: cGMP: Generators, Effectors and Therapeutic Implications; Harald H. H. W. Schmidt,Franz Hofmann,Johannes-Pet Book 2009 Springer-Verlag Ber

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Phosphodiesterases in the Central Nervous Systemand cAMP signaling is achieved by cGMP-dependent modulation of PDEs hydrolyzing cAMP and vice versa. Mammals posses at least 21 PDE genes and often express a set of PDEs in a tissue- and differentiation-dependent manner. Given these premises, it is still a challenging task to elucidate the physiolog

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NO-Independent, Haem-Dependent Soluble Guanylate Cyclase Stimulators CFM-1571, BAY 41-2272, BAY 41-8543, and BAY 63-2521. In contrast to the NO- and haem-independent sGC activators such as BAY 58-2667, these compounds stimulate sGC activity independent of NO and also act in synergy with NO to produce anti-aggregatory, anti-proliferative, and vasodilatory effects. Re

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NO- and Haem-Independent Soluble Guanylate Cyclase Activators and pharmacological properties. Both compounds are capable of selectively activating the oxidized/haem-free enzyme via binding to the enzyme‘s haem pocket, causing pronounced vasodilatation. The potential importance of these new drugs resides in the fact that they selectively target a modified stat

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Cyclic GMP-Hydrolyzing Phosphodiesteraseswerful and selective physiological process in its own right. Sutherland and colleagues reasoned that for cNs to be biologically relevant, there must be a mechanism for their removal from the cellular milieu. In 1958 they reported that heart extracts contained PDE activity that dampened or terminated

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cGMP: Generators, Effectors and Therapeutic Implications

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0171-2004 ention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic..978-3-642-08848-3978-3-540-68964-5Series ISSN 0171-2004 Series E-ISSN 1865-0325

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