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Titlebook: cGMP: Generators, Effectors and Therapeutic Implications; Harald H. H. W. Schmidt,Franz Hofmann,Johannes-Pet Book 2009 Springer-Verlag Ber

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Novel Techniques for Real-Time Monitoring of cGMP in Living Cellsime and in intact living cells. These techniques are based on the use of cGMP sensors, which respond to cGMP with changes in transmembrane ion current or changes in fluorescence. Here, we describe the principles of these techniques, compare them in terms of sensitivity and discuss possible application for current cell biology and physiology.
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Michael I. Axelrod,Michael L. Santagataime and in intact living cells. These techniques are based on the use of cGMP sensors, which respond to cGMP with changes in transmembrane ion current or changes in fluorescence. Here, we describe the principles of these techniques, compare them in terms of sensitivity and discuss possible application for current cell biology and physiology.
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Harald H. H. W. Schmidt,Franz Hofmann,Johannes-PetIncludes supplementary material:
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Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/d/image/242722.jpg
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Luis Pastor,Jose Maria Sebastianecome clear that the functional characteristics of PDEs and their role in cyclic nucleotide signaling are fairly complex. On the one hand, members of the PDE family responsible for the hydrolysis of cGMP affect cellular responses by shaping cGMP signals derived from the activation of soluble cytosol
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Knowledge Base for Structural Designth regulatory N-terminal tandem GAF domains, GAF-A and GAF-B, of four mammalian phosphodiesterases (PDEs) and of two cyanobacterial adenylyl cyclases (ACs) which bind cyclic nucleotides. These tandem GAFs are preceded by N-terminal sequences of variable lengths and a function of their own. In mammal
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