Titlebook: Clinical Trials in Neurology; Roberto J. Guiloff (Consultant Neurologist) Book 2001 Springer-Verlag London 2001 Ethical Issues.Parkinson.c

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Assessment Measures and Clinical Scalesand unobservable variables such as disability, mood and health-related quality of life. In this chapter we begin by defining measurement and outlining the advantages of using standardised measurement methods. Then, we explain why it is important to measure variables such as disability and how they can be measured rigorously using Likert scales.

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Advances in Artificial Intelligenceby many to be the father of the randomized clinical trial [3], later applied the concepts of randomization to the field of medicine during the 1940s. Hill’s viewpoint, which now has wide acceptance, was that randomized clinical trials are necessary for the valid assessment of therapeutic efficacy [4].

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Lecture Notes in Computer Science then review the desirable characteristics of instruments for evaluating dementia treatments, followed by a discussion of specific cognitive and other assessment instruments along with data on the extent to which they meet certain desirable validity, reliability and practicality criteria we detail below.

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César García-Díaz,Arjen van Witteloostuijntrying to harmonise the requirements for developing and marketing drugs, which includes harmonising the requirements for GCP. A harmonised guideline for GCP was issued in 1996 for implementation in Europe from 17 January 1997.

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Ethics, Outcome Variables and Clinical Scales: The Clinician’s Point of Viewshould predominate in such instances. In terms of the Declaration of Helsinki: “Concern for the interest of the subject must always prevail over the interests of science and society” [1,2]. The ethical aspects of research in neurology in no way differ from those in most other branches of medicine.