Titlebook: Clinical Trials in Neurology; Roberto J. Guiloff (Consultant Neurologist) Book 2001 Springer-Verlag London 2001 Ethical Issues.Parkinson.c

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Statistical Analysis of Repeated-Measures Data with Drop-outst arises in this context is missing data caused by subjects dropping out prior to the end of the study. For earlier discussions of this topic, see Heyting et al. [1], Gornbein et al. [2], Little and Schenker [3] or Little [4]. This chapter reviews some approaches to statistical analysis when faced w

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Outcome Variables in Dementia Trials: Conceptual and Practical Issuesal clinical scales and functional scales) in evaluating treatments for dementia, most especially Alzheimer’s disease (AD), with emphasis on neuropsychological assessment in trials of drugs designed to treat cognitive symptoms. We begin with a brief overview of issues in the diagnosis of dementia. We

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Fidel Aznar,Mar Pujol,Ramón Rizotatus and developing trends. This is all that will be attempted in this chapter. More extensive coverage of various statistical issues affecting drug development will be found in Senn [6]. The European Statistical Guideline [7] and International Conference on Harmonisation E9 Guideline are also extr

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Parallelisation of the PC Algorithmmation on nonrespondents, namely maximum likelihood based on repeated-measures models, and multiple imputation. Methods are illustrated on an intent-to-treat analysis of data from a randomized clinical trial for tacrine in the treatment of Alzheimer’s disease, reported in detail in Little and Yau [5

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Tamarafinide V. Dittimi,Ching Y. Suenically, yet in life the diagnosis can usually only be made clinically. Moreover, the considerable heterogeneity and broad spectrum of impairment that occurs is difficult to measure in a reliable way. From the earliest clinical trials in AD, drug regulatory authorities, and particularly the US Food a

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Advances in Artificial Intelligencethrombolytic therapy [12] in cerebral infarction. There are trials in progress of many other potentially promising treatments such as angioplasty for symptomatic carotid stenosis [13] and neuroprotective treatments for acute ischaemic stroke [3].