Titlebook: Clinical Trials in Neurology; Roberto J. Guiloff (Consultant Neurologist) Book 2001 Springer-Verlag London 2001 Ethical Issues.Parkinson.c

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The Intention-to-Treat Principle for Clinical Trialsby many to be the father of the randomized clinical trial [3], later applied the concepts of randomization to the field of medicine during the 1940s. Hill’s viewpoint, which now has wide acceptance, was that randomized clinical trials are necessary for the valid assessment of therapeutic efficacy [4].

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Omar O. Elrawy,Tamer S. Hamza,Samir S. Hosnyntions. To justify this important role in research these measurement methods must demonstrate that they are reliable and valid indicators of abstract and unobservable variables such as disability, mood and health-related quality of life. In this chapter we begin by defining measurement and outlining

Pde5-Inhibitors

Basma Elbeah,Abeer Elshater,Ahmed Toamaommunity. Some important rules for conduct of scientific research, e.g. clinical trials, arise from these obligations. Occasionally there may be a conflict between the different kinds of loyalty that medical scientists are supposed to cultivate. Obviously the obligations towards individual patients

悬崖

Olivier Brandoy,Philippe Mathieurs ago [1]. Effective drugs were, however, sparse until this century despite the advances of civilisation and science. Many ineffective remedies survived, the early physicians and patients being deluded by the self-limiting nature of many diseases and the “placebo effect”. Progress was often precipi

Influx

Alexander Gorobets,Bart Nooteboom undertake clinical trials without obtaining official approval and could market a product once the manufacturer was satisfied with the data which had been obtained. The only official controls came through the various poison control measures and through the Therapeutic Substances Act which set out re