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Titlebook: Clinical Experiences with Budipine in Parkinson Therapy; Franz Gerstenbrand,Werner Poewe,Gerald Stern Conference proceedings 1985 Springer

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Peng Wen,Yuefeng Li,Guoyin Wang981) and may also induce dyskinesias and paranoid symptoms. For these reasons “classical” antiparkinsonian agents like the anticholinergics and amantadine have regained importance in the treatment of early Parkinson’s disease (Fahn and Calne 1978) as well as adjuvants when levodopa dosage has to be reduced because of side effects.
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,Therapeutic Possibilities in On-Off Phenomena in Parkinson’s Disease,s. Tiapride is able to reduce disturbing peak dose dyskinesia or paroxysmal dyskinesia. An hourly observation system enables the more correct determination of the type of on-off phenomena and the selection of the medicament of choice.
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,Target and Additive Drugs in the Treatment of Parkinson’s Disease: A Pilot Study,treatment of choice. Such drugs are target drugs, while others acting on various other sites of neurotransmission (i.e. cholinergic, serotonergic, GABAergic systems) and influencing the dopaminergic activity indirectly are additive drugs.
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Wei Zhang,Duoqian Miao,Can Gao,Xiaodong Yuerbidopa and benserazide) that blocked the conversion of levodopa to dopamine by L-aromatic amino acid decarboxylase. These enzyme inhibitors were chosen because they did not readily cross the blood-brain barrier, so they did not impede the formation of dopamine in the striatum.
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