Titlebook: Clinical Experiences with Budipine in Parkinson Therapy; Franz Gerstenbrand,Werner Poewe,Gerald Stern Conference proceedings 1985 Springer

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The Pharmacodynamics of Budipine on Central Neurotransmitter Systems, the techniques available to us, we tried to shed some more light on the possible pharmacodynamic mechanisms of budipine. We used two in vivo tests: the locomotor activity (LA) test and the Porsolt swim test, as well as in vitro investigations on synaptosomes prepared from discrete rat brain areas,

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James Parkinson and the Treatment of His Disease,g contemporary knowledge of the pathophysiology of Parkinsons’s disease its treatment and the assessment of a new agent, it may give us a salutory sense of historical perspective to consider the past so that we can judge more critically recent achievements. James Parkinson (1755–1824) was a general

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,Dopaminergic Agonists and Receptors: Their Relevance to the Treatment of Parkinson’s Disease,cused on achieving increased activation of striatal dopaminergic receptors. Initially, this end was accomplished by administering the precursor of dopamine, levodopa; certain unwanted effects of this amino acid, notably nausea and vomiting, were alleviated by concomitant administration of drugs, (ca

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,Brain Dopaminergic Receptor Changes in Parkinson’s Disease in Relation to the Disease Process and Tnges in the pathophysiology of Parkinson’s disease (Ehringer and Hornykiewicz 1960). Besides these presynaptic changes of dopaminergic neurons, in recent years there have also been found alterations in dopaminergic receptors in the striatum (Reisine et al. 1977; Lee et al. 1978a; Rinne et al. 1979,