Titlebook: CNS Neuroprotection; Frank W. Marcoux (Vice President, Biology),Dennis Book 2002 Springer-Verlag Berlin Heidelberg 2002 Central Nervous S

gerontocracy

Neuroprotection by Free Radical Scavengers and Other Antioxidantsses are overwhelmed. The central nervous system is particularly sensitive to oxygen radical damage because of the high levels of polyunsaturated lipids present that, when peroxidized, compromise the integrity of neuronal cell membranes together with the specialized functions of those membranes.

BRUNT

Absenteeism

Stroke despite substantial effort and expense, no neuroprotective agent has yet been shown to improve clinical outcome in large, randomized multi-center trials. This review examines the data on neuroprotection in clinical stroke, with a focus on future directions for animal and human study.

HALO

Neurohormonal Signalling Pathways and the Regulation of Alzheimer ,-Amyloid Metabolism Integrating B or aggregability of A., consistent with a pathogenic role in AD. Other genetic loci for FAD have been discovered which are distinct from the immediate regulatory and coding regions of the APP gene, indicating that defects in molecules other than APP can also specify cerebral amyloidogenesis and FAD

Buttress

厚颜

Limiting Apoptosis as a Strategy for CNS Neuroprotectionth (. and . 1995). Necrosis usually applies to cell death that occurs to a group of cells or part of an organ in vivo, but the term has more recently been applied to cells in culture. Necrosis is the form of cell death which usually occurs when cells were injured by extreme physical stress or chemic