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Titlebook: CNS Neuroprotection; Frank W. Marcoux (Vice President, Biology),Dennis Book 2002 Springer-Verlag Berlin Heidelberg 2002 Central Nervous S

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发表于 2025-3-21 16:53:23 | 显示全部楼层 |阅读模式
书目名称CNS Neuroprotection
编辑Frank W. Marcoux (Vice President, Biology),Dennis
视频video
概述Includes supplementary material:
丛书名称Handbook of Experimental Pharmacology
图书封面Titlebook: CNS Neuroprotection;  Frank W. Marcoux (Vice President, Biology),Dennis  Book 2002 Springer-Verlag Berlin Heidelberg 2002 Central Nervous S
描述"CNS neuroprotection" was a common subject of papers, symposia, and reviews during the previous "decade of the brain. " Indeed, in recent years, experimental study of putative neuroprotective agents prompted clinical trials of numerous drug candidates in acute and chronic human neurodegenerative conditions. While the outcomes of these trials have not been as successful as initially hoped, these were early explorations, and the pipeline of relevant ideas continues to grow in strength and depth. We predict that early in this new millennium, crippling disorders such as stroke and Alzheimer‘s disease will be treated effectively by therapeutic neuroprotective strategies. This volume of the Handbook of Experimental Pharmacology titled eNS Neuroprotection provides a pharmacological perspective on currently promis­ ing neuroprotective approaches, and a clinical perspective on the challenges involved in establishing the efficacy of these approaches through appropriate clinical trials. Section I, "Mechanistic Approaches to CNS Neuroprotection," reviews major injury mechanisms that have formed the basis for many past and present clinical trials conducted around the world. Dr. KIM and colleagu
出版日期Book 2002
关键词Central Nervous System; Chemokine; Gentherapie; Nervous System; Neurodegenerative Disease; Neuropharmakol
版次1
doihttps://doi.org/10.1007/978-3-662-06274-6
isbn_softcover978-3-642-07625-1
isbn_ebook978-3-662-06274-6Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer-Verlag Berlin Heidelberg 2002
The information of publication is updating

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Our World is a Narrative World,n the patient’s family, the health care system, and society in general. The National Head and Spinal Cord Injury Survey estimates the rate of occurrence of severe head injury at 200 per 100000 (. et al. 1996). Motor vehicle accidents are the primary cause of both brain and spinal cord injury, and young healthy males are the primary victims.
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Traumatic Central Nervous System Injuryn the patient’s family, the health care system, and society in general. The National Head and Spinal Cord Injury Survey estimates the rate of occurrence of severe head injury at 200 per 100000 (. et al. 1996). Motor vehicle accidents are the primary cause of both brain and spinal cord injury, and young healthy males are the primary victims.
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,Introduction Narrative’s Lost Body,m in this pathologic sequence has prompted the development of glutamate and calcium receptor antagonists. Unfortunately, these strategies have not produced in humans the degree of protection observed in animal models of acute necrotic stroke (. and . 1999).
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Narrationen in der politischen Bildunging specificity for blocking Ca. and Na. channels have proven to be neuroprotective in various animal models. Several of these have been studied in placebo-controlled clinical trials. Unfortunately, to date, none of these compounds has unequivocally reduced human brain damage from stroke, cardiac arrest, or head trauma.
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Sodium and Calcium Channel Blockersing specificity for blocking Ca. and Na. channels have proven to be neuroprotective in various animal models. Several of these have been studied in placebo-controlled clinical trials. Unfortunately, to date, none of these compounds has unequivocally reduced human brain damage from stroke, cardiac arrest, or head trauma.
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