Titlebook: CNS Neuroprotection; Frank W. Marcoux (Vice President, Biology),Dennis Book 2002 Springer-Verlag Berlin Heidelberg 2002 Central Nervous S

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,Introduction Narrative’s Lost Body,ex vivo gene therapy. The direct injection of genes into the CNS using viral vectors or DNA-liposome suspensions is termed in vivo gene therapy. Ex vivo gene therapy is based on genetic modification of cells in vitro followed by the grafting of these cells into the CNS. Ex vivo approaches to gene therapy will be the focus of this review.

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Limiting Apoptosis as a Strategy for CNS Neuroprotectionchromatin fragments (in a punctuate fashion) all over the nuclei. Eventually, the nuclei become leaky and ultimately the plasma membrane ruptures. At least under in vitro conditions, necrosis is rapid and the time course of cell death is usually within 1–5-h death (. and . 1995).

Delirium

Ex Vivo Gene Therapy in the Central Nervous Systemex vivo gene therapy. The direct injection of genes into the CNS using viral vectors or DNA-liposome suspensions is termed in vivo gene therapy. Ex vivo gene therapy is based on genetic modification of cells in vitro followed by the grafting of these cells into the CNS. Ex vivo approaches to gene therapy will be the focus of this review.

同步信息

Narrating the Past through Theatreonotropic and metabotropic receptors (. et al. 1981; . and . 1987; . and . 1994). Under pathological conditions, glutamate receptor overactivation can trigger neuronal death, a phenomenon known as excitotoxicity (. and . 1957; . 1969). Incentive for developing practical methods for blocking excitoto

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https://doi.org/10.1057/9781137275424th (. and . 1995). Necrosis usually applies to cell death that occurs to a group of cells or part of an organ in vivo, but the term has more recently been applied to cells in culture. Necrosis is the form of cell death which usually occurs when cells were injured by extreme physical stress or chemic

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Introduction: A Decade under Construction,er the upregulation or induction of adhesion molecules and the release of biologically active substances, are collectively termed .. The inflammatory response is not antigen-specific and occurs following all modes of tissue injury, including traumatic, ischemic, and infectious insults. In infection,

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Narratives and Pragmatic Arguments: Ivens’ ,ny different neurological disorders, with a focus on cerebral ischemia. I will not attempt to review the extensive literature supporting the involvement of calcium in ischemic injury to neurons (see . 1995; . and . 1996 for review), but rather will provide selected examples of such evidence, togethe

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