Titlebook: CNS Neuroprotection; Frank W. Marcoux (Vice President, Biology),Dennis Book 2002 Springer-Verlag Berlin Heidelberg 2002 Central Nervous S

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Our World is a Narrative World, despite substantial effort and expense, no neuroprotective agent has yet been shown to improve clinical outcome in large, randomized multi-center trials. This review examines the data on neuroprotection in clinical stroke, with a focus on future directions for animal and human study.

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Narrative Con/Texts in Dubliners or aggregability of A., consistent with a pathogenic role in AD. Other genetic loci for FAD have been discovered which are distinct from the immediate regulatory and coding regions of the APP gene, indicating that defects in molecules other than APP can also specify cerebral amyloidogenesis and FAD

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Book 2002lved in establishing the efficacy of these approaches through appropriate clinical trials. Section I, "Mechanistic Approaches to CNS Neuroprotection," reviews major injury mechanisms that have formed the basis for many past and present clinical trials conducted around the world. Dr. KIM and colleagu

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Blocking Excitotoxicitytroke remains open, and there are other possible disease targets yet to be explored. Ongoing delineation of the cellular and molecular underpinnings of excitotoxicity has led to the progressive unveiling of countermeasures, aimed at attenuating presynaptic glutamate release, postsynaptic receptor ac

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