Overview: The production of a book devoted to Vaccine Protocols has proved to be a complex task; the variety of procedures required to design, develop, pro duce, and assess a vaccine is immense and covers aspects of chemistry, bio chemistry, molecular biology, and immunology. Many of the previous volumes in the Methods in Molecular Biology series provide the background required for work on vaccines; of particular interest are the volumes on Immunochemi cal Protocols, Practical Molecular Virology, Proteins, and Nucleic Acids. In the volume on Vaccine Protocols, we have tried to cover the lat
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