Titlebook: Mechanisms and Consequences of Proton Transport; Tetsuro Urushidani,John G. Forte,George Sachs Book 2002 Springer Science+Business Media N

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Human Nongastric H,K-ATPase: Current View On Structure And Functional Propertiesss biological membranes. All of these ion pumps share a common feature: formation of a phosphorylated intermediate during the reaction cycle (26,39). Different K.-dependent animal ATPases (X,K-ATPases) are the most closely related among various P-type ATPases. All of the known X,K-ATPases function a

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HKcαEncodes Ouabain-insensitive H,K-ATPase in Surface Cells of Rat Distal Colonwith normal renal function and normal dietary intake of sodium and potassium is modest; but in the presence of reduced renal function (e.g., anephric patients on hemodialysis) and during variation of dietary K intake, the colon adapts and become an important site for both K absorption and secretion.

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Mutational Analysis of Gastric Proton Pump, α- and β-Subunitsarietal cells, and K. from outside to inside of the cells, coupled with the hydrolysis of intracellular ATP to ADP and inorganic phosphate, resulting in the generation of more than 10. fold proton gradient across the apical membrane. Gastric proton pump consists of two kinds of subunits. One is the

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Structure-Activity Relationships of Na,K-ATPase and H,K-ATPaseh X,K-ATPases share many similarities, they have different ion specificities (Na. vs. H.) and different affinities for specific inhibitors (ouabain vs. SCH 28080). How do these enzymes discriminate between the different cations transported? What determines the specific binding of an inhibitor? It is

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The Effect of Mutations Within a Cluster of Homologous Amino Acids Present in the M5, M6 and M8 Tranen identified as a putative cation binding site. To test if these conserved amino acids influence the K. -stimulated ATPase activity of the H, K -ATPase, site mutations were introduced into the alpha-subunit of the rabbit gastric H, K -ATPase and co-expressed with the rabbit gastric beta-subunit in

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H,K,-ATPase, the Dominant Gastric Autoantigen in , Infectionwas given to its ability to cause peptic ulcers, much of the current focus is on its causative role in gastric cancer. Gastric cancer ranks second in malignancy-associated mortality, and in certain regions in The People’s Republic of China this mortality amounts to 70/100.000/year.