Titlebook: Genetic Epidemiology; Methods and Protocol Evangelos Evangelou Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018

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Meta-Analysis of Common and Rare Variants,dies, and is extensively used in the genomic analyses of complex traits. Estimates from different studies are combined and the results effectively provide the power of a much larger study. Meta-analysis also has the potential of discovering heterogeneity in the effects among the different studies. T

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Gene-Gene and Gene-Environment Interactions,e been made in identifying genetic variants associated with complex traits through more dense panels of genetic variants and larger sample sizes, genome-wide interaction analyses are still limited in power to detect interactions with small effect sizes, rare frequencies, and higher order interaction

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Genetic Association in the HLA Region,forts to pinpoint drivers of this commonly encountered association peak at the short arm of chromosome 6, however, have been challenging, owing to the high density of genes and the long and extended linkage disequilibrium that are characteristic of this region..The development of methods to impute c

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Multivariate Methods for Meta-Analysis of Genetic Association Studies,recision of the analysis. Here, we review, summarize and present in a unified framework methods for multivariate meta-analysis of genetic association studies and genome-wide association studies. Starting with the statistical methods used for robust analysis and genetic model selection, we present in

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