Titlebook: Genetic Epidemiology; Methods and Protocol Evangelos Evangelou Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018

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https://doi.org/10.1007/978-3-662-26053-1forts to pinpoint drivers of this commonly encountered association peak at the short arm of chromosome 6, however, have been challenging, owing to the high density of genes and the long and extended linkage disequilibrium that are characteristic of this region..The development of methods to impute c

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Das Methoden-Repertoire von Lehrerntion studies (GWAS) have successfully identified many genetic markers related to human diseases, the traditional statistical methods are not powerful to detect rare genetic markers. The rare genetic markers are usually grouped together and tested at the set level. One of such methods is the sequence

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https://doi.org/10.1007/978-3-531-91774-0ntive strategies will eventually decrease burden of diseases and thus precise prediction plays a crucial role in public health. Many investigators put efforts into finding models that improve prediction using known risk factors of diseases. Recently with the overwhelming load of genetic loci discove

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Das Mikroskop und Seine Anwendung,s and study the effects of certain treatments, diseases, and developmental stages. The traditional way to perform such experiments is to design oligonucleotide hybridization probes that correspond to specific genes and then measure the expression of the genes in order to determine which of them are

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Das zusammengesetzte Mikroskop,vational epidemiology. The advent of genome-wide association studies and the increasing accumulation of summarized data from large genetic consortia make MR a powerful technique. In this review, we give a primer in MR methodology, describe efficient MR designs and analytical strategies, and focus on

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