Titlebook: Gene Delivery; Huayu Tian,Xuesi Chen Living reference work 20210th edition Gene carriers.Gene therapy.Antitumor.Gene editing.Cationic pol

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Preparation and Evaluation of Boronate-Linked Nanoassembly for Efficient Gene Delivery,combinational therapy in view of the rapid chemotherapeutic action. However, little attention has been paid to the “rapid” goal in vector-aided transfection process. This chapter describes a boronate-linked nanoassembly for the rapid transnuclear gene transport and efficient gene transfection in vit

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Preparation and Evaluation of Lipopeptides with Arginine-Rich Periphery for Gene Delivery,ication. The present protocol focuses on synthesis, preparation, characterization of the gene carriers, including gene transfection efficiency evaluation as well as intracellular tracking. The synthesis of dendritic lipopeptides with bio-reducible disulfide linkage and dual aliphatic chains was firs

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Preparation and Evaluation of Multistage Delivery Nanoparticle for Efficient CRISPR Activation In Ve expression at the transcriptional level without causing damage to genomic DNA, providing a safer and natural tool to treat cancers. However, due to the conflicting surface requirements for different delivery stages, the development of drug delivery system for CRISPR/dCas9-based cancer gene therapy

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Preparation and Evaluation of Polymeric Hybrid Micelles to Co-Deliver Small Molecule Drug and siRNAecules to the cytoplasm of target cells still remains a huge challenge for the application in vivo. Here, this protocol describes a practical approach to prepare a highly flexible polymeric hybrid micelles for the in vivo delivery of siRNA. The micelles consist of cationic polycaprolactone-polyethyl

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Preparation and Evaluation of Rationally Designed Polymers for Efficient Endosomal Escape of siRNA,e expression of any interest gene. However, delivery is the most complicated and challenging process that hampers the wide application of siRNA. Rapid and efficient escape of siRNA from endosome to cytoplasm constitutes a determinant factor for gene silencing. In this chapter, we provide a detailed

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Jim T. Smith,Nicholas A. Beresfordp of mPEG-.-PBYP and the azide group of DOX-.-N.. And the polycationic carrier (abbreviated as mPEG-.-PBYP-.-DAE) is obtained . the thiol-yne “click” reaction between mPEG-.-PBYP and 2-dimethylaminoethanethiol hydrochloride (DAE). The structures of mPEG-.-PBYP-.-DOX and mPEG-.-PBYP-.-DAE are charact

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