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Titlebook: G-Quadruplex Nucleic Acids; Methods and Protocol Danzhou Yang,Clement Lin Book 2019 Springer Science+Business Media, LLC, part of Springer

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书目名称G-Quadruplex Nucleic Acids
副标题Methods and Protocol
编辑Danzhou Yang,Clement Lin
视频video
概述Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
丛书名称Methods in Molecular Biology
图书封面Titlebook: G-Quadruplex Nucleic Acids; Methods and Protocol Danzhou Yang,Clement Lin Book 2019 Springer Science+Business Media, LLC, part of Springer
描述This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful .Methods in Molecular Biology. series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.. .Practical and cutting-edge, .G-Quadruplex DNA: Methods and Protocols. is a valuable resource for both novice and experienced researchers who work in biophysics, structural biology, computational biology, biochemistry, and molecular and cell biology, and who want to learn more about the potential roles and effects of G-quadruplex in these fields. . ..
出版日期Book 2019
关键词FRET; Mass Spectrometry; G4 sequencing; DNAzyme; Biofilm; nucleic acid secondary structure
版次1
doihttps://doi.org/10.1007/978-1-4939-9666-7
isbn_softcover978-1-4939-9668-1
isbn_ebook978-1-4939-9666-7Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media, LLC, part of Springer Nature 2019
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,Newton and Leibniz – Giants and Opponents,rocesses including gene transcription, translation, replication, and genomic stability. G-quadruplexes are also found in nonhuman genomes, particularly those of human pathogens. Therefore, G-quadruplexes have emerged as a new class of molecular targets for drug development. In addition, there is con
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32nd Hemophilia Symposium Hamburg 2001topology. Now, with the advent of affordable, commercially sourced and purified synthetic DNA and RNA molecules suitable for immediate crystallization trials, and combined with the availability of specialized and validated crystallization screens, researchers can now undertake in-house crystallizati
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,Beendigung des Arbeitsverhältnisses,rase is incapable to resolve G-quadruplex structure and pauses at 3′-end of the G-quadruplex forming region when it transverses to the 5′-end of the template. Results from the DNA polymerase stop assay can provide the basis for further studies aimed at elucidating the major G-quadruplexes formed by
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,Sicht I: Die Weit-Sicht des Visionärs, and have been linked to regulation of gene expression in cancer and other diseases. Although molecules that bind to G4s, with subsequent influence on gene expression, have been well documented, the identification of new chemical scaffolds that potently and selectively bind to G4s and control specif
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Electrophoretic Mobility Shift Assay and Dimethyl Sulfate Footprinting for Characterization of G-Quation of G-quadruplexes, which can be used to deduce the guanine bases involved in the formation of G-tetrads under physiological salt conditions. DMS footprinting can also reveal important information in G-quadruplex-protein complexes on protein contacts and regional changes in DNA G-quadruplex upo
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