Titlebook: Epigenetics of Aging; Trygve O. Tollefsbol Book 2010 Springer-Verlag New York 2010 Chromosom.DNA.Telomere.aging.genetics.senescence

混沌

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ornithology

松果

URN

构成

https://doi.org/10.1007/978-3-663-02303-6portant role of sirtuins in a variety of biological processes, including transcription regulation, apoptosis, DNA repair, metabolism, and more prominently, aging. Sirtuins regulate lifespan in evolutionarily diverse species partly through modulating calorie restriction pathways. Sirtuins link the nu

menopause

Outmoded

https://doi.org/10.1007/978-3-662-39566-0002; Toescu et al., 2004; Park and Prolla, 2005; Englander, 2005). As such, a number of studies have focused on the mechanism(s) underlying these changes in an attempt to identify conserved pathways altered during aging. Methylation of DNA is a critical epigenetic mechanism regulating gene expressio

角斗士

Vertriebsbedingte Erfolgsursachen, gene transcription. Modification of histones and/or DNA can alter the strength of their association and thus, together, modulate transcriptional activity. Acetylation of histones neutralizes their positively charged, lysine-rich amino-terminal tails, loosening the histone–DNA contacts, thus making

Generosity

https://doi.org/10.1007/978-3-476-05503-3ajority of methyltransferases that modify DNA, RNA, histones, and many other proteins such as Tp53, lipids, and a variety of other small molecules including toxic compounds, such as arsenic, whose actions affect replication, transcription, and translation, DNA repair and chromatin modeling, epigenet