Titlebook: Epigenetics of Aging; Trygve O. Tollefsbol Book 2010 Springer-Verlag New York 2010 Chromosom.DNA.Telomere.aging.genetics.senescence

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Chromatin in Senescent Cells: A Conduit for the Anti-Aging Effects of Wnt Signaling? evidence that Wnt signaling can be both pro- and anti-aging. Here we discuss the idea that, in at least some cell and tissue contexts, Wnt signaling might antagonize aging through its ability to regulate chromatin structure in senescent cells.

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Kurt H. Stapf,Wolfgang Stroebe,Klaus Jonasontributing to the development of chronic age-related human pathological states. This review describes the involvement of DNA hypomethylation in the pathogenesis of several major age-related human diseases, including cancer, atherosclerosis, Alzheimer’s disease, psychiatric disorders, and autoimmune pathologies.