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Titlebook: Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3; Kenneth V. Honn,Lawrence J. Marnett,Patrick Y.-K.

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Function and Regulation of Prostaglandin Synthase-2tors (1). One of these genes encodes the inducible form of prostaglandin synthase (2), now known as PGS-2 or cyclooxygenase 2 (COX-2). We demonstrated that the product of the PGS-2 gene has both cyclooxygenase and hydroperoxidase activities (3); that PGS-2 is a functional prostaglandin synthase. At
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Characterization and Molecular Cloning of Mouse Type II Phospholipase A2ransduction. PLA. also provides precursors for eicosanoid generation when the cleaved fatty acid is arachidonic acid, or platelet-activating factor (PAF) formation when the .-1 position of the phosphatidylcholine (PC) contains an alkyl ether linkage. Recent advances in molecular and cellular biology
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Differential Activation of Keratinocyte Phospholipase A2S by Tumor Promoters and other Irritantsransduction and tumor promotion. The tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) and other irritants, including the calcium ionorphore A23187, elicit the release of the fatty acids from which these compounds are derived (1). Phospholipase A. (PLA.) plays a key role in regulating the re
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