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Titlebook: Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3; Kenneth V. Honn,Lawrence J. Marnett,Patrick Y.-K.

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楼主: 威风
发表于 2025-3-28 17:42:10 | 显示全部楼层
0065-2598 Overview: 978-1-4899-1815-4978-1-4899-1813-0Series ISSN 0065-2598 Series E-ISSN 2214-8019
发表于 2025-3-28 19:51:09 | 显示全部楼层
Bernd Pelster,Warren W. BurggrenLOX and the arachidonate metabolite generated via 12-LOX activity, 12(.)-HETE, have been shown to contribute to the metastatic potential of tumor cells in vivo and in vitro 4. Most recently, elevated expression of 12-LOX mRNA in prostate epithelial cells was demonstrated to correlate with poor prognosis in human prostate cancer..
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https://doi.org/10.1007/978-1-349-02062-1hapter will summarize the known characteristics of COX-1 deficient mice and describe some future studies utilizing these mice which will lead to a better understanding of the physiological functions of the COX’s and their roles in the therapeutic and toxic effects of NSAIDs (non-steroidal anti-inflammatory drugs).
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Studies on the Active Site of Leukotriene A4 Hydrolaseate LTA. into the proinflammatory compound LTB., 5(S), 12(R)-dihydroxy-6, 14-.-8, 10-.-eicosa-tetraenoic acid (For reviews see Refs. 1 and 2). Sequence comparisons of LTA. hydrolase with certain zinc containing proteases and peptidases led to the discovery of a zinc binding motif in the primary stru
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EGF-Receptor Tyrosine Kinase and 12-Lipoxygenase Activity Regulate Expression of 12-Lipoxygenase in LOX and the arachidonate metabolite generated via 12-LOX activity, 12(.)-HETE, have been shown to contribute to the metastatic potential of tumor cells in vivo and in vitro 4. Most recently, elevated expression of 12-LOX mRNA in prostate epithelial cells was demonstrated to correlate with poor progn
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Role of 12-HPETE in the Pathogenesis of Cerebral Vasospasmts occurrence correlates to the presence and the amount of subarachnoid clot. It is different from ordinary constriction of vessel, since the cerebral vasospasm is delayed onset and long lasting contraction of the vessel which also involves histological changes. Although almost all substances which
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Involvement of the Multiple Tumor Suppressor Genes and 12-Lipoxygenase in Human Prostate Cancerly regulate cell growth. To date, a number of tumor suppressor genes (e. g., RB, p53, DCC, APC/MCC, NF1, NF2, WT1, VHL, BRCA1, MST1, and WAF1/CIP1 genes) have been identified and have been shown to be important in a variety of human malignancies such as cancers of the colon, lung, breast, and esopha
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