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Titlebook: Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3; Kenneth V. Honn,Lawrence J. Marnett,Patrick Y.-K.

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https://doi.org/10.1007/978-94-009-6729-8ain more than one enzyme, each of which is regulated independently and has distinct functions. Thus, cytosolic PLA. (cPLA.) and two types of secretory PLA.s (type I and type II) are the best characterized members of a still expanding large family of mammalian PLA. s..
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Víctor Ramiro Fernández,Gabriel Brondinothe formation of different eicosanoids (2). This eventually would lead to the differing biological responses. This paper focuses on the differential activation of different forms of PLA. and identifies and characterizes two forms of PLA., namely the cytosolic (cPLA.) and secretory (sPLA.) forms in mouse epidermal keratinocytes.
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Oxidized Low Density Lipoprotein Stimulates Protein Kinase C (PKC) Activity and Expression of PKC-Isenase/cyclooxygenase inhibitor ML 3000 and by treatment with N-(2-cyclohexy-loxy-4-nitrophenyl)methane sulfonamide (NS-398). Thesse results suggest a predominantly COX 2-dependent and isotype-specific effect of modified (lipo)proteins on PKC.
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Characterization and Molecular Cloning of Mouse Type II Phospholipase A2ain more than one enzyme, each of which is regulated independently and has distinct functions. Thus, cytosolic PLA. (cPLA.) and two types of secretory PLA.s (type I and type II) are the best characterized members of a still expanding large family of mammalian PLA. s..
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EGF-Receptor Tyrosine Kinase and 12-Lipoxygenase Activity Regulate Expression of 12-Lipoxygenase in LOX and the arachidonate metabolite generated via 12-LOX activity, 12(.)-HETE, have been shown to contribute to the metastatic potential of tumor cells in vivo and in vitro 4. Most recently, elevated expression of 12-LOX mRNA in prostate epithelial cells was demonstrated to correlate with poor prognosis in human prostate cancer..
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Disruption of the Mouse Cyclooxygenase 1 Genehapter will summarize the known characteristics of COX-1 deficient mice and describe some future studies utilizing these mice which will lead to a better understanding of the physiological functions of the COX’s and their roles in the therapeutic and toxic effects of NSAIDs (non-steroidal anti-inflammatory drugs).
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Amita Singh,Milap Punia,Thiyam Bharat Singhate LTA. into the proinflammatory compound LTB., 5(S), 12(R)-dihydroxy-6, 14-.-8, 10-.-eicosa-tetraenoic acid (For reviews see Refs. 1 and 2). Sequence comparisons of LTA. hydrolase with certain zinc containing proteases and peptidases led to the discovery of a zinc binding motif in the primary stru
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