Titlebook: DNA Topoisomerase Protocols; Volume II: Enzymolog Neil Osheroff,Mary-Ann Bjornsti Book 2001 Humana Press 2001

Neutropenia

agitate

Armand Graaff,Danie Smit,Sunet Eybersing a 3′-DNA covalent intermediate and a 5′-terminus (5′-OH). Strand ligation occurs during a second transesterification event when the 5′-OH displaces the enzyme (. .). A change in DNA linking number results when strand unwinding occurs between these cleavage and ligation reactions.

Irksome

ICE Bioassay,the cleavage site. This ability of topoisomerases to catalyze concerted breaking and rejoining of DNA strands makes them biologically important enzymes that are involved in crucial cellular processes (.–.).

惊惶

Quinolone Interactions with DNA and DNA Gyrase,ocess of drug design by furthering our understanding of the established structure-activity relationship of that class of compounds. The method has been best exemplified by the investigations of mode of action of quinolone antibacterials that target the bacteria-specific type II DNA topoisomerase, DNA gyrase (reviewed in . .–.).

cathartic

Bactericidal Assays for Fluoroquinolones,ented in many other organisms, indicating that DNA gyrase is a universal target for these drugs. This relationship has been somewhat complicated recently by the observation that in ., mutations in another type II enzyme, topoisomerase IV, also confer resistance to fluoroquinolones (.).

白杨鱼

沟通

,Synthesis and Use of DNA Containing a 5′-Bridging Phosphorothioate as a Suicide Substrate for Type ing a 3′-DNA covalent intermediate and a 5′-terminus (5′-OH). Strand ligation occurs during a second transesterification event when the 5′-OH displaces the enzyme (. .). A change in DNA linking number results when strand unwinding occurs between these cleavage and ligation reactions.

腼腆

Fawwaz Mohammed,Lisa F. Seymourthe cleavage site. This ability of topoisomerases to catalyze concerted breaking and rejoining of DNA strands makes them biologically important enzymes that are involved in crucial cellular processes (.–.).

严厉批评

https://doi.org/10.1007/978-3-030-95070-5ocess of drug design by furthering our understanding of the established structure-activity relationship of that class of compounds. The method has been best exemplified by the investigations of mode of action of quinolone antibacterials that target the bacteria-specific type II DNA topoisomerase, DNA gyrase (reviewed in . .–.).

Occlusion