| 书目名称 | DNA Topoisomerase Protocols | | 副标题 | Volume II: Enzymolog | | 编辑 | Neil Osheroff,Mary-Ann Bjornsti | | 视频video | | | 丛书名称 | Methods in Molecular Biology | | 图书封面 |  | | 描述 | Beginning with the Escherichia coli ? protein, or bacterial DNA topoisomerase I, an ever-increasing number of enzymes have been identified that catalyze changes in the linkage of DNA strands. DNA topoisomerases are ubiquitous in nature and have been shown to play critical roles in most p- cesses involving DNA, including DNA replication, transcription, and rec- bination. These enzymes further constitute the cellular targets of a number of clinically important antibacterial and anticancer agents. Thus, further studies of DNA topology and DNA topoisomerases are critical to advance our und- standing of the basic biological processes required for cell cycle progression, cell division, genomic stability, and development. In addition, these studies will continue to provide critical insights into the cytotoxic action of drugs that target DNA topoisomerases. Such mechanistic studies have already played an important role in the development and clinical application of antimicrobial and chemotherapeutic agents. The two volumes of DNA Topoisomerase Protocols are designed to help new and established researchers investigate all aspects of DNA topology and the function of these enzymes. The chapte | | 出版日期 | Book 2001 | | 版次 | 1 | | doi | https://doi.org/10.1385/1592590578 | | isbn_softcover | 978-1-61737-057-1 | | isbn_ebook | 978-1-59259-057-5Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2001 |
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发表于 2025-3-21 18:39:32
