Titlebook: DNA Topoisomerase Protocols; Volume II: Enzymolog Neil Osheroff,Mary-Ann Bjornsti Book 2001 Humana Press 2001

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Armand Graaff,Danie Smit,Sunet Eybersdiester bonds. Strand cleavage is not the result of phosphodiester hydrolysis, but the result of transesterification of an active-site tyrosine, creating a 3′-DNA covalent intermediate and a 5′-terminus (5′-OH). Strand ligation occurs during a second transesterification event when the 5′-OH displace

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Thokozile Manaka,Terence van Zyl,Deepak Kar effects or toxicity. DNA unwinding results in a lengthening of the double helix. This increase in length can be detected by physicochemical (such as electric dichroism) or hydrodynamic methods (such as viscosity and sedimentation measurements) using short segments of linear DNA. These methods mostl

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https://doi.org/10.1007/978-3-030-95070-5ecades; however, critical information linking the physical-chemical properties associated with these complexes with their biological effectiveness remains unclear. Significant progress has been made toward unraveling the structural and dynamic properties of many ligand-DNA complexes, which has provi

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Edgar Jembere,Aurona J. Gerber,Anban Pillayxert their lethality on . by inhibiting the normal function of the DNA gyrase (a bacterial topoisomerase II) in this organism. Mutations around a limited region of the DNA gyrase A subunit (residues Ala67-Gln106) have been shown to confer resistance to these agents in . (.). This has also been docum

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