Titlebook: Cytokine Knockouts; Scott K. Durum,Kathrin Muegge Book 19981st edition Springer Science+Business Media New York 1998 Colon.Vivo.cytokine.c

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,Mice Deficient in Interleukin-1β Converting Enzyme,L-1α and IL-1β of which IL-1β is the predominant form released by human monocytes in culture. IL-1β is synthesized as a 31-kDa precursor devoid of a conventional signal sequence and is processed to its active 17-kDa form by an enzyme called IL-1β converting enzyme (ICE) which has an unique cleavage

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IL-6 Unique Functions in Inflammation, Bone Metabolism, and B-Cell Neoplasias Revealed by Studies otion of B-lymphocytes into antibody-producing plasma cells and the activation of T-cells, and it stimulates proliferation and differentiation of hematopoietic stem cells and thymocytes (for review . ref. .). IL-6 is also a central mediator of several host responses to acute inflammation, including t

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NF-IL6 Knockout Mice,hin an interleukin (IL)-1 responsive element in the human IL-6 gene .. The cloning of the cDNA encoding human NF-IL6 revealed that it shows a high degree of homology with C/EBP in the carboxy-terminal basic and leucine zipper domains, responsible for DNA binding and dimerization, respectively .. NF-

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Disruption of the LIF Receptor,lular signal (for reviews . refs. . and 2). Leukemia inhibitory factor (LIFR) binds LW that is converted to high affinity binding by heterodimerization with gp130. Other ligands that use the LIFR are oncostatin M (OSM) and cardiotrophin-1 (CT-1). CT-1 utilizes LIFR although all the receptor componen

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,Phenotypes of TGFß Knockout Mice,nt advances have been made recently in understanding the functions of these molecules in vivo by the targeted ablation of various members of the super gene family. The family members include the TGF(is, activins, inhibins, bone morphogenetic proteins, Müllerian-inhibiting substance, nodal, dorsalin,

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