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Titlebook: Cytokine Knockouts; Scott K. Durum,Kathrin Muegge Book 19981st edition Springer Science+Business Media New York 1998 Colon.Vivo.cytokine.c

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https://doi.org/10.1057/978-1-137-54786-6f, and is a major factor in acute inflammation, being responsible for the activation and chemotaxis of neutrophils to the site of acute injury .. Neutrophils provide the first line of defense in fighting infection by destroying bacteria with phagocytosis and the release of super oxides and peroxides
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https://doi.org/10.1057/978-1-137-54786-6terferons was the inhibition of virus replication. Only much later did it become apparent that, as is characteristic of cytokines in general, interferons have many pleiotropic activities, including modulating effects on the rate of cell growth and a variety of actions on functions of the immune syst
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https://doi.org/10.1007/978-3-030-26376-8tion of B-lymphocytes into antibody-producing plasma cells and the activation of T-cells, and it stimulates proliferation and differentiation of hematopoietic stem cells and thymocytes (for review . ref. .). IL-6 is also a central mediator of several host responses to acute inflammation, including t
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, – Einheit und Vielfalt der Arbeitlular signal (for reviews . refs. . and 2). Leukemia inhibitory factor (LIFR) binds LW that is converted to high affinity binding by heterodimerization with gp130. Other ligands that use the LIFR are oncostatin M (OSM) and cardiotrophin-1 (CT-1). CT-1 utilizes LIFR although all the receptor componen
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, – Einheit und Vielfalt der Arbeitnt advances have been made recently in understanding the functions of these molecules in vivo by the targeted ablation of various members of the super gene family. The family members include the TGF(is, activins, inhibins, bone morphogenetic proteins, Müllerian-inhibiting substance, nodal, dorsalin,
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