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Titlebook: Catalytic RNA; Fritz Eckstein,David M. J. Lilley Book 1997 Springer-Verlag Berlin Heidelberg 1997 AIDS.HIV.Nucleotide.RNA.biology.catalysi

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N. Aslimani,E.-G. Talbi,R. Ellaia (Buzayan et al. 1986; Hutchins et al. 1986; Prody et al. 1986). The consensus sequence required for bond cleavage consists of a “core” of nucleotides at the juncture of three base-paired stems (Fig. la; Forster and Symons 1987; Ruffner et al. 1990). Although the hammerhead ribozyme was originally c
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Lecture Notes in Computer Sciencelogical systems (Symons 1991; Pyle 1993). The hammerhead ribozyme is a relatively small RNA catalyst that is derived from a structural motif present in the RNA genomes of several plant pathogens, where it is believed that RNA-mediated cleavage events are an essential step in the viroid’s replication
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Aleksandr Beznosikov,Alexander Gasnikov (Altman 1989; Cech 1989; Michel et al. 1989; Noller et al. 1992; Symons 1992; Bratty et al. 1993; Gesteland and Atkins 1993). Of all these catalytic RNAs, the hammerhead ribozyme is the smallest. Naturally occurring hammerhead ribozymes were identified initially within RNA viruses and they act in .
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Maria Stefanova,Stanislav Baklanovhas led to the design of short oligoribonucleotides that are able to function in . as specific endoribonucleases (Uhlenbeck 1987; Haseloff and Gerlach 1988). The naturally occurring self-cleavage reaction plays a central role in the rolling circle replication of these pathogenic RNAs (Symons 1989).
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Maria Stefanova,Stanislav Baklanovt motifs, and catalyze RNA cleavage and RNA splicing reactions (Symons 1989). For the hammerhead and hairpin ribozyme motifs identified in the (+) and (−) strands of the satellite RNA of tobacco ringspot virus, the cleavage reactions are intramolecular. However, dissection of the catalytic motifs ha
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