Titlebook: Cardiovascular Biology of Purines; Geoffrey Burnstock,James G. Dobson,Joel Linden Book 1998 Springer Science+Business Media New York 1998

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Molecular Biology and Pharmacology of Recombinant Adenosine Receptors, but can activate phospholipase C via G protein βγ subunits, but the A. receptor desensitizes much more slowly. The A. and A. receptors both couple to Gs, but theA. receptor also can couple to Gq to mobilize calcium.

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Regulation of Adenosine Receptor Subtypes and Cardiac Dysfunction in Human Heart Failure,RNA was not detectable. However, A.-adenosine receptor gene expression was increased by about 60% in patients with dilated cardiomyopathy. Thus, the A.-upregulation may indicate a pathophysiological role for adenosine and adds therefore to the increasingly complex picture of molecular alterations in heart failure.

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Robert Boardman,James F. Keeleycellular adenosine concentration is normally very low and adenosine is continuously formed extracellularly from released adenine nucleotides, the concentration gradient for adenosine in the normoxic heart is from extracellular to intracellular. This gradient is rapidly reversed during hypoxia or pharmacological inhibition of adenosine kinase.

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影响深远

Vascular Biology and Pharmacology of Adenosine Receptors,les of adenosine (Tucker and Linden, 1992; Muller et al., 1996; Olsson, 19%; Ongini and Fredholm, 1996; Feoktistov and Biaggioni, 1997) allow the authors to focus this review on important new developments that have occurred over the past two or three years. Readers wanting a broader understanding should consult those earlier articles.