Titlebook: Cardiovascular Biology of Purines; Geoffrey Burnstock,James G. Dobson,Joel Linden Book 1998 Springer Science+Business Media New York 1998

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Vascular Biology and Pharmacology of Adenosine Receptors,denosine research began 35 years ago, when Berne (1963) and Gerlach et al. (1963) independently proposed that adenosine controls hypoxic coronary vasodilation. The eve of those anniversaries is a fitting time to review the actions of adenosine on blood vessels. Some older reviews (Belardinelli et al

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Debility

Adenosine, KATP Channel, and Cardioprotection in the Intact Heart,icacious therapeutics for treating myocardial ischemia. Of particular interest is the adenosine-K. axis. Development of the interest in this area was based on the intersection of several independent lines of investigation. The interest in preconditioning brought the K. and adenosine researchers toge

atrophy

Adenosine Receptor Subtypes and Cardioprotection in Cardiac Myocyte and Transgenic Models,used on improving the blood supply to the ischemic myocardium, recent discoveries of myocardial adaptive protective mechanisms have re-focused therapeutic attention on the heart muscle. Adenosine is released in large amounts during ischemia and has been shown to mediate a number of important cardiop

atrophy

Regulation of Adenosine Receptor Subtypes and Cardiac Dysfunction in Human Heart Failure,e four adenosine receptor subtypes A., A., A., A. and the A.-mediated antiadrenergic signal transduction pathway has been studied in nonfailing and failing human hearts. Gene expression of myocardial A.-adenosine receptors and A.-mediated inhibitory effects on cAMP levels or negative inotropic effec

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Adenosine and Cardiac Arrhythmias, 1929]. These potent properties and its short half life in vivo have allowed adenosine to establish its place as a unique and invaluable tool for both elucidating the mechanism of cardiac arrhythmias and for treating supraventricular tachycardia.

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Adenosine and Cardiac Aging, in a greater manifestation of the antiadrenergic action of adenosine reducing ß-adrenergic responsiveness. Results suggest that despite similar adenosine production by young adult and aged myocardium, elevated basal interstitial adenosine levels in aged myocardium result from depressed . activity o

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