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Titlebook: Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures; Boris R. Minev Book 2011 Springer Scienc

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Targeting the TumorMicroenvironment for Enhancing Chemotherapy in HematologicMalignanciesproduced by both the tumor cell as well as by cells surrounding the tumor. These surrounding cells, such as bone marrow stromal cells, together with the extracellular matrix, cytokines and growth factors, and blood vessels, comprise the tumor microenvironment. This microenvironment provides a safe h
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Adoptive Immunotherapy of Cancer Using Autologous Lymphocytesg to investigate. It is the most important to define and establish a suitable culture system that can permit adequate expansion of effector lymphocytes with sufficient activities that can persist in vivo. It must also be of importance to conduct scientific clinical trials for establishing effective
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https://doi.org/10.1007/978-981-97-5685-8h are preferentially activated by tumor cells have been developed. Among those, TLK286, a glutathione S-transferase P1–1 activated prodrug that elicits cytotoxicity against cancer cells but has bone marrow sparing activities, is one example. This compound may be a forerunner of new anticancer drugs
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Gabriel Andy Szalkowski,Jan Arild Audestadation including SN-38, 9-aminocamptothecin (9-AC), 9-Nitrocamptothecin (9-NC), lurtotecan (GI-47211), rubitecan, OSI-211, exatecan mesylate (DX8951f), diflomotecan (BN80915), gimatecan (ST1481), CKD-602, DB-67, and karenitecin (BNP1350). The advancement of these agents and further development within
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https://doi.org/10.1007/978-981-97-5685-8-based therapeutic uses, common toxicities, and problems with resistance. We briefly review other folate antagonists as well. In conclusion, methotrexate and other antifolates are important cytotoxic drugs used alone or in combination with other medications for the treatment of a wide variety of mal
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