Titlebook: Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures; Boris R. Minev Book 2011 Springer Scienc

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Elise M. Barrella,Mary Katherine Watsonranging from the treatment of diabetes to wound healing. Of the over fifty alkaloids present in minute quantities within the plant, only two (vincristine and vinblastine) have been isolated, synthesized, and are widely used as chemotherapeutic agents [1, 2]. The antitumor activity of the vinca alkal

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https://doi.org/10.1007/978-981-97-5685-8idines, alkyl sulfonates, epoxides, nitrosoureas and triazene compounds. Due to their chemical properties, these drugs can, either directly or after biological activation react and form covalent bonds with macromolecules such as DNA, RNA and proteins. Their cytotoxic properties are mainly associated

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https://doi.org/10.1007/978-981-97-5685-8 French groups [7, 38]. The Italian group focused on natural product analogues, and isolated doxorubicin from the . variant, and the French group produced semi-synthetic derivates [6]. Although a vast number of analogues were synthesized after these initial discoveries, only two other anthracyclines

FLING

Gabriel Andy Szalkowski,Jan Arild Audestadarious human malignancies. Camptothecin (CPT) was originally isolated in 1966 from the bark and stem of the native Chinese tree, . [155]. Although camptothecin demonstrated promising antitumor effects in animal systems, its utility was compromised in the clinical setting because of erratic absorptio

悲痛

https://doi.org/10.1007/978-981-97-5685-8gimens against many solid and hematologic malignancies, including acute lymphoblastic lymphoma (ALL), choriocarcinoma, osteosarcoma, lymphoma, and cancers of the breast, bladder, and head and neck. Lower doses are given to treat several nonmalignant diseases, including rheumatoid arthritis, systemic

SLING

Gabriel Andy Szalkowski,Jan Arild Audestadnt of many solid tumor types. When combined with other cytotoxic drugs or some of the newer “targeted” agents, significant improvements in response and survival rates have been observed in cancers of the ovary, lung, bladder and head and neck. Its most remarkable contribution, however, has been in t