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Titlebook: Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures; Boris R. Minev Book 2011 Springer Scienc

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Alkylating Agentsh are preferentially activated by tumor cells have been developed. Among those, TLK286, a glutathione S-transferase P1–1 activated prodrug that elicits cytotoxicity against cancer cells but has bone marrow sparing activities, is one example. This compound may be a forerunner of new anticancer drugs
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Topoisomerase I Inhibitors – The Camptothecinsation including SN-38, 9-aminocamptothecin (9-AC), 9-Nitrocamptothecin (9-NC), lurtotecan (GI-47211), rubitecan, OSI-211, exatecan mesylate (DX8951f), diflomotecan (BN80915), gimatecan (ST1481), CKD-602, DB-67, and karenitecin (BNP1350). The advancement of these agents and further development within
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Folate Antagonists-based therapeutic uses, common toxicities, and problems with resistance. We briefly review other folate antagonists as well. In conclusion, methotrexate and other antifolates are important cytotoxic drugs used alone or in combination with other medications for the treatment of a wide variety of mal
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Effects of Cancer Chemotherapy on Gonadal Functionts currently receive chemotherapy than ever before and, of greater significance, many more individuals are cured of their tumors and survive to experience the potential late adverse effects of such treatment. Among these, infertility and mutagenesis are often of particular concern to cancer survivor
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