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Titlebook: Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures; Boris R. Minev Book 2011 Springer Scienc

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Anthracyclines and Anthracenediones French groups [7, 38]. The Italian group focused on natural product analogues, and isolated doxorubicin from the . variant, and the French group produced semi-synthetic derivates [6]. Although a vast number of analogues were synthesized after these initial discoveries, only two other anthracyclines
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Topoisomerase I Inhibitors – The Camptothecinsarious human malignancies. Camptothecin (CPT) was originally isolated in 1966 from the bark and stem of the native Chinese tree, . [155]. Although camptothecin demonstrated promising antitumor effects in animal systems, its utility was compromised in the clinical setting because of erratic absorptio
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Platinum Complexes for the Treatment of Cancernt of many solid tumor types. When combined with other cytotoxic drugs or some of the newer “targeted” agents, significant improvements in response and survival rates have been observed in cancers of the ovary, lung, bladder and head and neck. Its most remarkable contribution, however, has been in t
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Targeting the TumorMicroenvironment for Enhancing Chemotherapy in HematologicMalignanciesumor development and that all of the clinical properties of a tumor, including response to therapy, depend heavily on the tumor stroma. We have much less understanding of the biology and genetics of stroma-tumor interactions than we do of tumor cells. Despite recent advances in the treatment of canc
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