Titlebook: Calcium Entry Pathways in Non-excitable Cells; Juan A. Rosado Book 2016 The Editor(s) (if applicable) and The Author(s), under exclusive l

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Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca2+) Permeable Non-selective Cation Chctive cation channels. The gene encoding the TRPC7 channel plasma membrane protein was first cloned from mouse brain. TRPC7 mRNA and protein have been detected in cell types derived from multiple organ systems from various species including humans. G.-coupled protein receptor activation is the predo

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The Calcium Entry-Calcium Refilling Couplinging between Ca. entry and Ca. refilling is playing a central role in this Ca. homeostasis. Since the capacitative Ca. entry has been described, different mechanisms have been proposed in order to explain how the Ca. entry could be under control of intracellular store Ca. depletion. Today, in additio

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Microdomains Associated to Lipid Raftse affected in several pathologies including cancer. The basic molecular constituents of SOCE are Orai, the pore forming unit, and STIM, a multidomain protein with at least two principal functions: one is to sense the Ca. content inside the lumen of the endoplasmic reticulum(ER) and the second is to

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Phospholipase A2 as a Molecular Determinant of Store-Operated Calcium Entrywere suggested as agonists of store operated calcium channels (SOCC) and other TRP channels. Herein, we will review the important role of iPLA. on the intracellular Ca. handling focusing on its role in SOCE regulation and its implication in physiological and/or pathological processes.

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0065-2598 ritical analysis of the current observations and directions Calcium entry pathways in non-excitable cells presents a concise synthesis of thoughtfully selected topics covering from the different calcium entry mechanisms in non-excitable cells to the cellular microdomains and organelles regulating th