| 书目名称 | Calcium Entry Pathways in Non-excitable Cells |
| 编辑 | Juan A. Rosado |
| 视频video | |
| 概述 | Provides an extensive overview of the mechanisms underlying calcium entry in non-excitable cells.Includes relevant background information, critical analysis of the current observations and directions |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | Calcium entry pathways in non-excitable cells presents a concise synthesis of thoughtfully selected topics covering from the different calcium entry mechanisms in non-excitable cells to the cellular microdomains and organelles regulating the calcium entry process. Particular attention is given to the fascinating group of ion channels involved in different calcium entry pathways as well as the emerging role of these channels in human disease. Calcium entry is an essential mechanism for cellular function in non-excitable cells. In general, two main calcium entry pathways exist in non-excitable cells: one pathway, named store-operated calcium entry (SOCE) requires store depletion and the second pathway is regulated by receptor occupation, but independently on calcium store depletion. The search for the molecular components of calcium entry has identified the stromal interaction molecule 1 (STIM1), as the calcium sensor of the intracellular calcium stores, and Orai as well as TRP channelsas the calcium-permeable channels located in the plasma membrane. The location, interactions and function of these channels are finely regulated by a number of scaffolding proteins, membrane microdomai |
| 出版日期 | Book 2016 |
| 关键词 | STIM1; Orai1; TRP channels; Calcium entry; Cellular microdomains |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-26974-0 |
| isbn_softcover | 978-3-319-80050-9 |
| isbn_ebook | 978-3-319-26974-0Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
发表于 2025-3-21 19:45:51
