Titlebook: Calcium Entry Pathways in Non-excitable Cells; Juan A. Rosado Book 2016 The Editor(s) (if applicable) and The Author(s), under exclusive l

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Gerd Witt,Andreas Wegner,Jan Sehrtl members of the TRPC family of channels also take part of the SOC macromolecular complex. This introductory chapter summarizes the early pieces of evidence that led to the concept of SOCE and the components of the store-operated signaling pathway.

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Gerd Witt,Janick Ambrosy,Fabian Neugebauern the plasmamembrane. The identification of STIM1 and Orai1 and recently the structural resolution of both proteins by X-ray crystallography and nuclear magnetic resonance substantiated many findings from structure-function studies which has substantially improved the understanding of CRAC channel a

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Neue Entwicklungen in der Dermatologieminus. Intriguingly, TRPC1 function is not only dependent on STIM1 but also requires Orai1. The critical functional interaction between TRPC1 and Orai1, which determines the activation of TRPC1, has also been identified. In this review, we will discuss current concepts regarding the role of TRPC cha

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J. Hunyadi,M. Simon Jr.,O. P. HornsteinPC3 functions to atherogenesis has recently began to receive validation through studies in mouse models of atherosclerosis with conditional gain or loss of TRPC3 function. This chapter summarizes these novel findings and provides a discussion of their impact in the context of atherosclerosis, in an

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Die Hexachlorbenzol (HCB)-Porphyrie,ilization via a range of routes such as amplification of G-protein-coupled receptor-dependent Ca. responses. This chapter also considers the mechanism by which cells generate extracellular ATP for autocrine or paracrine activation of P2X1 receptors. For example cytosolic ATP efflux can result from o

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O. P. Hornstein,U. W. Schnyder,J. Schönfeld building of signaling complexes. The scaffolding proteins are involved in the assembling of these Ca. signaling complexes, the correct sub-cellular localization of protein partners, and the regulation of the TRPC channelosome. In particular, these proteins, via their multiple protein–protein intera