Titlebook: Validation of Alternative Methods for Toxicity Testing; Chantra Eskes,Maurice Whelan Book 2016 The Editor(s) (if applicable) and The Autho

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Validation of Alternative In Vitro Methods to Animal Testing: Concepts, Challenges, Processes and Td suites, data sources and decision-aiding tools. Data generated with alternative approaches are ultimately used for decision-making on public health and the protection of the environment. It is therefore essential that the underlying methods and methodologies are thoroughly characterised, assessed

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Evidence-Based Toxicology,rivers spurring the development of EBT..In the context of pathway-based toxicology, EBT approaches, given their objectivity, transparency and consistency, have been proposed to be used for carrying out a (retrospective) mechanistic validation..In summary, implementation of more evidence-based approa

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Validation of Transcriptomics-Based , Methods,his chapter describes those aspects that were identified as important in the validation process of transcriptomics-based tests, including the assessment of standardisation, reliability and relevance. It also critically discusses the challenges posed to validation in relation to the specific characte

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Ensuring the Quality of Stem Cell-Derived , Models for Toxicity Testing,iative. Accordingly, the chapter summarizes the most up-date best practices in the use and quality control of human Pluripotent Stem Cell lines in the development of . toxicity assays from leading experts in the field.

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