Titlebook: Validation of Alternative Methods for Toxicity Testing; Chantra Eskes,Maurice Whelan Book 2016 The Editor(s) (if applicable) and The Autho

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Integrated Approaches to Testing and Assessment, models). Decision analytic methods derived from socioeconomic theory can also play a role in developing flexible and optimal IATA solutions. Some of the challenges involved in the development, validation and implementation of IATA are also discussed.

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0065-2598 technologies.An overview of innovative approaches to method.This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing

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Validation of Computational Methods, some of the current difficulties in addressing the residual uncertainties of read-across. Finally we put forward a perspective of how non-testing approaches may evolve in light of the advances in new and emerging technologies and how these fit within the Adverse Outcome Pathway (AOP) framework.

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Regulatory Acceptance of Alternative Methods in the Development and Approval of Pharmaceuticals,performing clinical trials in even larger populations, or before marketing authorisation, or to control quality during production. Ethical and animal welfare considerations require that animal use is limited as much as possible. Directive 2010/63/EU on the protection of animals used for scientific p

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