Titlebook: siRNA and miRNA Gene Silencing; From Bench to Bedsid Mouldy Sioud Book 2009 Humana Press 2009 Gene and immunotherapy.Gene regulation.In viv

BRUNT

Targeted Delivery of Antisense Oligonucleotides and siRNAs into Mammalian Cells,ll interfering RNA (siRNAs) can be delivered in vitro to virtually all cell types using lipid-based transfection agents or electroporation, efficient strategies for achieving either systemic or targeted delivery remains one of the major in vivo challenges. Among the targeting strategies, receptor-ta

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公理

Imaging of siRNA Delivery and Silencing,he efficiency of target gene silencing. The molecular imaging approach fits perfectly to fulfill these needs and provides information in a fast, reproducible, and noninvasive manner. This review serves as a first attempt to summarize existing information on various imaging modalities and their appli

Mendacious

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Substitution

Bacterial Delivery of siRNAs: A New Approach to Solid Tumor Therapy,RNAi-based therapies has been slow due to the lack of targeted delivery methods. The biggest challenge in the use of siRNA-based therapies is delivery to target cells. There are many additional obstacles to in vivo delivery of siRNAs, such as degradation by endogenous enzymes and interaction with bl

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pSM155 and pSM30 Vectors for miRNA and shRNA Expression,liferation, and organ development. miRNAs regulate gene function through a process termed RNA interference (RNAi), which is a highly conserved intracellular mechanism that regulates posttranscriptional gene silencing. RNAi is triggered by double-stranded small interfering RNAs (siRNAs), which can be

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