| 书目名称 | Systems Biology of RNA Binding Proteins |
| 编辑 | Gene W. Yeo |
| 视频video | |
| 概述 | Provides case studies of RNA binding proteins that regulate aspects of RNA processing.Focuses on global protein-RNA interactions to understand disease and development.First book on systems biology of |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | .After transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes. Similarly to DNA binding proteins such as transcription factors that regulate gene expression by binding to DNA elements in the promoters of genes, RBPs regulate the fate of target RNAs by interacting with specific sequences or RNA secondary structural features within the transcribed RNA molecule. The set of functional RNA elements recognized by RBPs within target RNAs and which control the temporal, functional and spatial dynamics of the target RNA define a putative “mRNP code”. These cis-regulatory RNA elements can be found in the 5’ and 3’ untranslated regions (UTRs), introns, and exons of all protein-coding genes. RNA elements in 5’ and 3’ UTRs are frequently involved in targeting RNA to specific cellular compartments, affecting 3’ end formation, controlling RNA stability and regulating mRNA translation. RNA elements in introns and exons are known to function as splicing enhancers or silencers during the splicing process from pre-mRNA to mature mRNA..This book provides case studies of RNA binding proteins that reg |
| 出版日期 | Book 2014 |
| 关键词 | Protein-RNA interactions; RNA Binding Proteins; RNA processing; systems biology; gene expression |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4939-1221-6 |
| isbn_softcover | 978-1-4939-5434-6 |
| isbn_ebook | 978-1-4939-1221-6Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
发表于 2025-3-21 19:28:26
