Titlebook: Systems Biology of RNA Binding Proteins; Gene W. Yeo Book 2014 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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Antisense Oligonucleotide-Based Therapies for Diseases Caused by pre-mRNA Processing Defects, and polyadenylation in the nucleus. Defects in the processing of pre-mRNAs due to mutations in RNA sequences often cause disease. Traditional small molecules or protein-based therapeutics are not well suited for correcting processing defects by targeting RNA. However, antisense oligonucleotides (AS

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Identification of miRNAs and Their Targets in ,, been associated with the control of virtually all biological processes and are known to play major roles in development and cellular homeostasis. Yet the biological roles of most miRNAs remain to be fully known. Furthermore, the precise rules by which miRNAs recognize their targets and mediate gene

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0065-2598 nd disease and development.First book on systems biology of .After transcription in the nucleus, RNA binding proteins (RBPs) recognize cis-regulatory RNA elements within pre-mRNA sequence to form mRNA-protein (mRNP) complexes. Similarly to DNA binding proteins such as transcription factors that regu

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