Titlebook: Systems Biology of RNA Binding Proteins; Gene W. Yeo Book 2014 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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Book 2014mRNP) complexes. Similarly to DNA binding proteins such as transcription factors that regulate gene expression by binding to DNA elements in the promoters of genes, RBPs regulate the fate of target RNAs by interacting with specific sequences or RNA secondary structural features within the transcribe

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Evolutionary Conservation and Expression of Human RNA-Binding Proteins and Their Role in Human Genever of all RNAs, often binding thousands of targets at many sites. The importance of RBPs is underscored by their dysregulation or mutations causing a variety of developmental and neurological diseases. This chapter globally discusses human RBPs and provides a brief introduction to their identificat

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Functional Analysis of Long Noncoding RNAs in Development and Disease,n integral part of the mammalian transcriptome. Recent work demonstrated that lncRNAs play multiple structural and functional roles, and their analysis has become a new frontier in biomedical research. In this chapter, we provide an overview of different lncRNA families, describe methodologies avail

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Genetic Variation and RNA Binding Proteins: Tools and Techniques to Detect Functional Polymorphisms genes and pathways in genetic model organism. Increasingly, this question is being asked in the clinic. Genomes of individuals and populations are being sequenced and compared. The challenge often comes at the stage of analysis. The variant positions are analyzed with the hope of understanding huma

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Genome-Wide Activities of RNA Binding Proteins That Regulate Cellular Changes in the Epithelial to essential for patterning of developing embryos and organs. The EMT/MET are further utilized in wound healing, but they can also be hijacked by cancer cells to promote tumor progression and metastasis. The molecular pathways governing these processes have historically focused on the transcriptional