Titlebook: Systems Biology; Nikolaus Rajewsky,Stefan Jurga,Jan Barciszewski Book 2018 Springer International Publishing AG, part of Springer Nature 2

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A Systems Perspective of Complex Diseases: From Reductionism to Integration, whole populations and beyond). This complex nature of both the common diseases and the human beings has kept researchers far from a holistic understanding of underlying biological processes. Over the past decade, there has been a rapid and vast accumulation of large scale high-throughput biological

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Systems Biology of Bacterial Immune Systems: Regulation of Restriction-Modification and CRISPR-Cas hese systems are regulated is necessary for both biotechnology applications, and for understanding how they modulate horizontal gene transfer (including acquisition of virulence factors). We here review results on modeling these systems which point to common general principles underlying their archi

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Systems Biology of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis,utations in genes encoding RNA-binding proteins (RBPs) have been known as a major culprit. RBPs are involved in almost every aspect of RNA metabolism events from synthesis to degradation. Characteristic features of RBPs in neurodegeneration include misregulation of RNA processing, mislocalization of

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,Systems Approaches to Map In Vivo RNA–Protein Interactions in ,,eins represent an important control mechanism to double check which proportion of nascent pre-mRNAs is ultimately available for translation into distinct proteins. Here, we discuss recent progress to obtain a systems-level understanding of in vivo RNA–protein interactions in the reference plant . us

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Systems-Level Analysis of Bacterial Regulatory Small RNA Networks,gged behind their identification, as few high-throughput approaches existed to capture sRNA interactions in vivo. Recently, methodologies have been described that allow for profiling of the sRNA interaction network facilitating systems-level analysis sRNA regulation. This chapter discusses recent ad

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Epioncogene Networks: Identification of Epigenomic and Transcriptomic Cooperation by Multi-omics Inlevel have the ability to affect how an entire network of cancer genes behaves, and thereby taking on an oncogenic role. Further, epigenetic factors cooperate and team up with transcription factors to control specific gene target networks. Transcriptomics in combination with epigenomic profiling and

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Is Autogenous Posttranscriptional Gene Regulation Common?,n is common. Several examples are known, mostly from bacteria, bacteriophage, and yeast species. Each was identified either by accident or by a concerted effort to understand the regulation of specific genes. The paucity of examples from higher eukaryotes may be due to the difficulty of identifying