Titlebook: Systems Biology; Nikolaus Rajewsky,Stefan Jurga,Jan Barciszewski Book 2018 Springer International Publishing AG, part of Springer Nature 2

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The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease, microRNAs (miRNAs) of around 23 nucleotides and long non-coding RNAs (lncRNAs) that are above 200 nucleotides in length. One of the first functional ncRNAs discovered was the lncRNA named . (.). . is the main actor in a fundamental process called X chromosome inactivation (XCI) where, in females, o

Foment

GRACE

Biophysical Analysis of miRNA-Dependent Gene Regulation, of the Argonaute family, they form RNA-induced silencing complexes, which bind target mRNAs, reducing their stability and translation rate. A miRNA typically has hundreds of evolutionarily conserved binding sites across the transcriptome, and frequently, a given mRNA carries binding sites for multi

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Modeling and Analyzing the Flow of Molecular Machines in Gene Expression,his process, macromolecules such as ribosomes or RNA polymerases scan the genetic material in a sequential manner. We review several deterministic, continuous-time models for the flow of such macromolecules. These models are both easy to simulate and amenable to rigorous mathematical analysis. We de

ULCER

Robust Approaches to Generating Reliable Predictive Models in Systems Biology,a. While doing so, an effective way of representing a network model is developed for computing purposes using adjacency matrix-like data structures. This allows models to include Uni-Uni to Bi-Bi reactions in addition to enzymatic activation and inhibition. It is demonstrated that the technique is e

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CORD

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