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Titlebook: Symposium in Immunology VI; Tumor Immunology Martha M. Eibl,Christoph Huber,Ulrich Wahn Conference proceedings 1997 Springer-Verlag Berlin

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Heat-Shock-Protein-Based Vaccines against Cancers and Intracellular Infectionsnactivated cancer cells are immune to subsequent challenges of live cancer cells. The phenomenon was shown to be individually tumor-specific, in that mice were immune specifically to the tumors that were used to immunize them and not to other tumors (Basombrio 1970; Globerson and Feldman 1964), hence the nomenclature . tumor rejection antigens.
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Characterization of Antigens Recognized by T Cells on Human Tumors involved in tumor rejection, can be cultured in vitro and used as tools to identify the target antigens expressed by the tumor cells (Boon et al. 1994). Tumor-specific CTLs have been found in most mouse tumor models, and in several human tumor types, mainly in melanoma. By using a genetic approach
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Shared and Individual CTL-Defined Antigens on Human Melanoma Cells intact proteins, but protein-derived peptides presented by HLA molecules on the cell surface. HLA-associated peptides originate from proteins of any cellular location. This allows T cells to survey the organism for any alteration occurring intracellularly and opens up an enormous variety of potenti
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Towards the Development of Immunogenic Colon Cancer Cells for Immunotherapyed to be the result of either a failure to induce resting pre-effector T lymphocytes to differentiate into effector cells or active mechanisms of immunosuppression which are exerted by tumor cells as soluble inhibitory activities. One must expect that both mechanisms play a role in the interaction b
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