Titlebook: Smad Signal Transduction; Smads in Proliferati Peter ten Dijke,Carl-Henrik Heldin Book 2006 Springer Science+Business Media B.V. 2006 evolu

浪荡子

泄露

Genetic Disruptions within the Murine Genome Reveal Numerous Roles of the Smad Gene Family in Develproliferation and differentiation, organogenesis, immunological response, wound healing, and tumorigenesis. Here we summarize these studies and discuss possible mechanisms underlying phenotypic alterations associated with the deficiency of each Smad

GLIB

cravat

,Gene Expression Signatures of TGF-β/Smad-Induced Responses,ified by systematic cross-referencing and functional annotation of published lists of TGF-β/Smad target genes. This work provides a valuable compendium for context-dependent analysis of transcriptional profiles of TGF-β/Smad signaling

Functional

不能逃避

Molecular Evolution of Smad Proteins, only within subfamilies. Conservation in the C-terminal receptor phosphorylation region provides new insight into a unique subfamily containing three interacting nematode proteins that signal for DAF-7. From a larger perspective, our analysis strongly supports the traditional view that flies are more closely related to humans than to nematodes

漫步

Neutropenia

Smad Proteins in Apoptotic and Survival Signaling,wledge of how the Smads function in the generation of cell death and survival aids in our understanding of developmental disorders and cancer in which defective cell death responses have been implicated

Aromatic

,TGF-β/SMAD Signaling in Epithelial to Mesenchymal Transition,iveness and metastasis on the one hand, and to fibrotic conditions on the other. Here we emphasize on mechanisms of signal transduction and specific gene targets of the TGF-β pathway that are critical effectors of EMT

驳船